Studies on the promoting phase in the stages of carcinogenesis in mice, rats, rabbits, and guinea pigs.
نویسنده
چکیده
In previous experiments by Berenblum and Shubik (4), tumors were induced in mice by a single application of a carcinogenic hydrocar bon, followed by repeated applications of noncarcinogenic croton oil. Friedewald and Rous (7) similarly showed that tumors may be induced in the rabbit by a suboptimal dose of carcinogen fol lowed by wound healing and applications of non specific agents, such as turpentine. Previously, Ber enblum (1) had shown that turpentine, as well as croton oil, had an augmenting (cocarcinogenic) effect in carcinogenesis in mice; and several other examples of this activity have been reviewed in the literature by Berenblum in 1944 and Rusch (15). Arising from this work, a new concept of carcino genesis has been proposed, involving an initiating stage, brought about by the hydrocarbon, with a small number of normal cells changing into latent tumor cells which are subsequently converted into morphological tumors by promoting action (e.g., croton oil, wound healing, etc.). The latent tumor cells remain irreversibly changed for 20 weeks (4) or even as long as 43 weeks (5). In the mouse, only croton oil can be said to have considerable promoting action, whereas other fac tors previously investigated, such as turpentine (1) and wound healing (6, 13) have a minimal ef fect. In the rabbit, on the other hand, both wound healing and turpentine seem to have a marked ef fect. Substances tested for possible promoting activi ty have usually been selected from those agents known to induce epidermal hyperplasia. Mice and rabbits have most frequently been employed for such tests. In the present study, a variety of sub stances, all inducing epidermal hyperplasia, was examined for possible promoting activity, and, in addition to mice and rabbits, rats and guinea pigs were also used.
منابع مشابه
A Survey on the Gastrointestinal Parasites of Rabbit and Guinea Pig in a Laboratory Animal House
There is documented evidence that infection in laboratory animals can often influence the outcome of experiments. All infections, apparent or inapparent, are likely to increase biological variability. As a research project concerning the diversity and distribution of parasites of rabbit and guinea pig in a conventional laboratory animal house, about 87 rabbits (from 700 ) and 105 guinea pigs (f...
متن کاملStudies on the rapid production of Foot and Mouth disease hypenmmune antisera in guinea pigs
متن کامل
Evaluation of the Effect of Onosma Bracteatum Wall (Boraginaceae) On Bronchial Hyperreactivity in Sensitized Guinea Pigs
Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Onosma bracteatum ( O. bracteatum ) is know...
متن کاملA comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs
Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (IP) with two strain of B. mallei. Ten male guinea ...
متن کاملEffect of Oral and Intramuscular Administration of Ivermectin in Guinea Pigs on Survival of Blood-feeding Anopheles stephensi under Insectary Conditions
Background and purpose: Insecticide resistance in mosquitoes particularly malaia may lead to reemergence of malaria epidemics. This study aimed to investigate the effect of oral and intramuscular administration of ivermectin on guinea pigs exposed to Anopheles stephensi mosquitoes, the main malaria vector. Materials and methods: The effect of ivermectin was studied in oral and intramuscular ad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 10 1 شماره
صفحات -
تاریخ انتشار 1950